Mutations in Norrin, Fzd4, LRP5, β-catenin, and Tspan12 are associated with inherited diseases of the retinal vasculature, most notably familial exudative vitreoretinopathy (FEVR) (Jiao et al., 2004; Nikopoulos et al., 2010; Panagiotou et al., 2017; Poulter et al., 2010; Robitaille et al., 2002; Shastry et al., 1997; Toomes et al., 2004), and therapeutic targeting of Norrin/β-catenin signaling shows promise for modulating the BRB and BBB (Chidiac et al., 2021; Ding et al., 2023; Nguyen et al., 2022; O’Brien et al., 2023; Phoenix et al., 2016). Here, FZD4 is linked to Familial exudative vitreoretinopathy.