Commercial efforts and research groups have included p.I157T (dbSNP: rs17879961) in polygenetic risk score calculations.16,17 Meanwhile, p.S428F (dbSNP: rs137853011) and p.T476M (dbSNP: rs142763740) were not included in these polygenetic risk score assessments.16,17 Polygenetic risk scores, which included the p.I157T single-nucleotide variation, have been used to estimate breast cancer risk among those with CHEK2 PVs18 and have been combined with the Tyrer-Cuzick model.19,20. The gene discussed is CHEK2; the disease is breast carcinoma.