Specific variants in CHEK2, such as p.I157T, p.S428F, and p.T476M, have lower ORs (1.1-1.4) and therefore are considered lower risk and have discordant classifications and an ambiguous effect on screening recommendations.6,7 Less is known about whether biallelic low-risk (LR) CHEK2 variants are associated with a specific cancer susceptibility phenotype. The gene discussed is CHEK2; the disease is cancer.