HMOX1 and cancer: Catalytic actiontoward the end products including biliverdin, Fe(II), and carbon monoxide,as well clearance of the cytotoxic heme, imparts HO-1 antioxidantand anti-inflammatory effects.2 Althoughthe basal HO-1 levels in healthy tissues are low, as an inducibleprotein, HO-1 is highly induced in cancer cells.