T. pyogenes is a primary pathogen for uterine infections, and purulent uterine disease in cows has been associated with endometrial cell sensitivity to the PLO exotoxin causing hemolysis and cytolysis and an inflammatory response from the host with an increase in the accumulation of IL-1β, IL-6, and IL-8 (54). This evidence concerns the gene CXCL8 and uterine disorder.