Furthermore, in addition to antagonizing the pro-tumorigenic Wnt/β-catenin signaling pathway (Jia et al., 2010), SOX17 functions as a tumor suppressor for several types of cancer in other endoderm-derived organs (Du et al., 2009; Kuo et al., 2014; Li et al., 2015). The gene discussed is SOX17; the disease is neoplasm.