SOX17 and cholestasis: The gross morphology and histology of livers from Sox17Δ50/GFPCre mice at P1, about a day before expected death, revealed signs of cholestasis, with increased blanching of the distal hepatic lobes due to necrosis, disruption of the hepatic capsule, and increased inflammation (Fig. 6B,D), features reminiscent of Sox17 heterozygous-null mice in a C57BL/6 background (Uemura et al., 2013).