NLRP3 and early-onset autosomal dominant Alzheimer disease: Figure 6(D) is a timeline visualization of keyword clustering, highlighting recent research hotspots such as ‘ovarian cancer,’ ‘nf-kappa-b,’ ‘Alzheimer’s disease,’ ‘acute myeloid leukaemia,’ ‘NLRP3 inflammasome,’ ‘inflammation,’ ‘lipid peroxidation,’ ‘breast cancer,’ ‘oxidative stress,’ and ‘molecular docking.’ These clusters indicate that current celastrol research focuses on anti-inflammatory, anticancer, and other related mechanisms.