TGFB1 and chronic rhinosinusitis with nasal polyps: Together with the pSMAD2/3 patterns in CRSwNP, these observations strongly suggested that differences in developmentally associated exposure to TGF-β across tissue microenvironments direct MC polarization in vivo and potentially implicated shorter-term TGF-β signaling as a factor differentiating MCTC1 and MCTC2 clusters.