Together with previous findings that SELE and its S149R mutation can serve as a prognostic marker for colon cancer (39), our results suggest that the SELE-S149R may likely enhance the adhesion properties of E-selectin in endothelial cells, reshaping the key TME component to support cancer progression (38), thereby affecting individual susceptibility to NPC. The gene discussed is SELE; the disease is colonic neoplasm.