Remarkably, among these pathways, 3 sentinel genes, including SELE, NOTCH3, and FGFR3, emerged as being involved in at least 2 NPC-associated pathways and being associated with NPC in the gene-based test at the P < 1 × 10–4 level (Figure 2A). The gene discussed is NOTCH3; the disease is nasopharyngeal carcinoma.