Here we conducted the most extensive WES association study on NPC to date, uncovering 3 genetic variants and genes linked to NPC susceptibility, including the common variant rs2276868 in RPL14, the rare coding variant rs5361 in SELE, and the common variant rs1050462 within the HLA-B locus. The gene discussed is HLA-B; the disease is nasopharyngeal carcinoma.