Subsequent siRNA screening of these candidates pinpointed 5 TFs capable of modulating RPL14 expression, with NKRF and E2F5 being particularly notable, whose knockdown significantly reduced RPL14 transcription in NPC cells (Figure 5, C and D, and Supplemental Figure 8, C, D, F, G). Here, E2F5 is linked to nasopharyngeal carcinoma.