This risk level is comparable to that of the top 20% of the population’s polygenic risk score (PRS) derived from HLA variants (OR = approximately 2.14–2.30) and exceeds the risk associated with the minor allele T of the common RPL14-rs2276868 variant (OR = 1.22~1.28) or the top 20% of the population’s PRS for NPC derived from non-HLA GWAS variants (OR = 1.31-1.80; Supplemental Figure 4) within the same Guangdong datasets. This evidence concerns the gene RPL14 and nasopharyngeal carcinoma.