Additionally, to observe the localized expression of Pan-Kla in neuronal cells, immunofluorescence staining experiments revealed that Pan-Kla significantly colocalized with microglia (CD11B), astrocytes (GFAP), and neurons (NEUN) in hippocampus tissue sections from 6-month-old WT mice and APP23/PS45 double-transgenic AD mice (Supplemental Figure 1, C–E). Here, RBFOX3 is linked to Alzheimer disease.