TRPV4 and obesity due to melanocortin 4 receptor deficiency: In studies involving rats, diminished TRPV4 expression and function have been associated with endothelial dysfunction in mesenteric arteries under conditions of genetic and salt‐induced hypertension (Boudaka et al. 2019; Gao et al. 2009; Seki et al. 2017), obesity (Ma et al. 2013), and aging (Du et al. 2016).