Activation of Nrf2 by topical treatment with apocarotenoid mitigated radiation-induced dermatitis in mice (Schmidlin et al., 2020), and cardamonin treatment activated Nrf2 in an oxazolone-induced AD mouse model, which suppressed Th2 cytokine production and protected from oxidative DNA and lipid damage (Yoo et al., 2020). The gene discussed is NFE2L2; the disease is Alzheimer disease.