One previous study reported higher [11C]PK11195 ligand binding associated with both global and deep CMBs in patients with mild cognitive impairment or Alzheimer disease.16 CMBs have also been associated with systemic inflammation as estimated by inflammation biomarkers, including E-selectin, vascular endothelial growth factor, CRP (C-reactive protein), TNFR2, and myeloperoxidase.15 This evidence concerns the gene CRP and early-onset autosomal dominant Alzheimer disease.