EGFR and squamous cell carcinoma: The rationale for using HSC3 cells was two-fold: these cells (1) have growth that is dependent on EGFR activity (Ohnishi et al., 2008; Pinilla-Macua et al., 2017), and (2) represent an experimental model of the squamous cell carcinoma of head-and-neck, a tumor type in which VAV2 is an emerging prognostic marker (Lorenzo-Martin et al., 2020).