TGM2 and aneurysm: In support of a prominent role for enzymes that affect both the cytoskeleton and ECM in aneurysm pathophysiology, tissue-type transglutaminase (TG2) expression was shown to be increased in the maximally dilated portion of human abdominal aorta aneurysmal samples compared to nondilated segments of the aorta (Shin et al., 2013).