TG2 has been shown to inhibit MMP-2, -9, and tumor necrosis factor (TNF)-α in primary cultures of human abdominal aortic aneurysm-derived smooth muscle cells, supporting the notion that TG2 stabilizes the ECM and prevents the progression of abdominal aortic aneurysm (Shin et al., 2013). This evidence concerns the gene MMP2 and abdominal aortic aneurysm.