Yang et al. reported that LT-α secreted by TILs promotes proliferation, migration and angiogenesis of endothelial cells by enhancing TNFR/NF-κB/PFKFB3-mediated glycolysis, which may lead to aberrant tumor angiogenesis and progression in HNSCC 137. The gene discussed is LTA; the disease is head and neck squamous cell carcinoma.