TMCO1 and malignant colon neoplasm: Additionally, inhibitor of apoptosis-stimulating protein of p53 (iASPP) maintains intracellular Ca2+ balance by preventing Gp78-mediated degradation of Ca2+-channel protein transmembrane and coiled-coil domains 1 (TMCO1), thereby inhibiting tumor cell growth and overcoming the resistance to therapeutic drugs in colon cancer 140.