Excess cellular iron is toxic, recent studies have found that OTUD1 acts as a deubiquitinating enzyme of iron-responsive element-binding protein 2 (IREB2), which can block its degradation, thereby promote the expression of transferrin receptor protein 1 (TFRC) and enhance cellular iron uptake, leading to increased intracellular ROS production and ferroptosis in CRC 79. This evidence concerns the gene IREB2 and colorectal carcinoma.