Of note, consistent with previous studies highlighting the close association between white matter injury and stroke outcomes 32, our behavior results were also highly correlated with the FA and RD values in both EC and IC of DTI on day 35 (Figure 1L), further supporting the pro-repair effect of HDAC3-miKO on post-stroke white matter as our previous preliminary evidence has indicated 30. The gene discussed is HDAC3; the disease is stroke disorder.