FOS and ovarian cancer: For instance, Huang et al. developed a photoactivated Pt(IV) prodrug skeleton polymer nanoparticle system (CNPPtCP/si(c-fos)) for controlled small interfering RNA of c-fos (si(c-fos)) delivery and synergistic photoactivated chemotherapy (PACT) and RNA interference (RNAi) in Pt-resistant ovarian cancer (Figure 5B) 76.