Comparative RNA-seq expression analysis between glioma patients, obtained from the astrocytoma IDH mut and GBM IDH wt cohorts from the TCGA database, showed significant overexpression of S100A2, S100A3, S100A4, S100A5, S100A6, S100A8, S100A9, S100A10, S100A11, S100A12 and S100A13 genes in IDH wt GBM compared to astrocytomas IDH mut (Supplementary Figure 1A-B), suggesting their possible relevance in the aggressiveness of this type of tumor. Here, S100A4 is linked to central nervous system cancer.