The results showed that S100A9 gene had a high expression in the necrotic and vascular areas of the tumor (identified by IHC staining of HIF-1α and CD34, respectively) (Figure 2J, 2K), while S100A11 was only representative in the vascular zones (Figure 2J, 2L) and S100A13 in the peripheral and infiltrating areas of the tumor (determined by GFAP IHC staining) (Figure 2J, 2M). This evidence concerns the gene S100A11 and neoplasm.