Additionally, infection of gonadotropin-releasing hormone (GnRH) neurons, which are crucial for regulating reproduction, or tanycytes, multifunctional hypothalamic glia that interact with GnRH neuron terminals, could contribute to hypogonadotropic hypogonadism (Sauve et al., 2023). The gene discussed is GNRH1; the disease is hypogonadotropic hypogonadism.