Research has demonstrated that SARS-CoV-2 S protein binds to TLR4 with greater affinity than to ACE2 (Choudhury and Mukherjee, 2020), leading to aberrant signaling that contributes to the hyperinflammatory response seen in COVID-19 patients (Aboudounya and Heads, 2021). Here, ACE2 is linked to COVID-19.