For instance, S100A15-L exhibits a more pronounced response to pro-inflammatory Th1 cytokines, such as TNF-α, IFN-γ, and IL-1β, than S100A15-S, which may explain its ~25 times greater expression than S100A150-S in acne lesions, as suggested for psoriasis (178, 208, 216). This evidence concerns the gene IFNG and acne.