ADSL and acne: To summarize, the developed anti-acne AMPs represent a diverse group of either cationic and anionic peptides (charge at pH 7.0 ranging from -3.1 to +10.9), with length ranging from 5 to 35 residues, and various physicochemical properties, such as aliphatic index (range from 26.1 to 214.0), Grand average of hydropathicity index) (range from -1.9 to 1.824), and instability index (range from -26.0 to 131.9) (Figure 8; Supplementary Table S1).