Anti-CCL3 monoclonal antibodies strongly inhibited joint injury and bone erosion in a collagen-induced arthritis (CIA) mouse model (28); AMG487, the antagonist of CXCR3, a receptor for chemokines CXCL9–11, also supressed RA in a CIA model (29). The gene discussed is CXCL9; the disease is rheumatoid arthritis.