In reverse MR analysis, GBM was found to be strongly associated with nine immunophenotypes based on FDR: BAFF-R on CD24+ CD27+ (FDR = 0.033), BAFF-R on IgD+ CD38- (FDR = 0.036), BAFF-R on IgD-CD38br (FDR = 0.039), BAFF-R on unsw mem (FDR = 0.048), BAFF-R on CD20- (FDR=0.012), HVEM on EM CD8br (FDR=0.036), CCR2 on myeloid DC (FDR = 0.035), CD45 on CD33-HLA DR+ (FDR = 0.004), and CD34 on HSC (FDR = 0.035). The gene discussed is CD33; the disease is glioblastoma.