To explore m6A methylation change in the livers of HCC patients, 17 samples of tissues (Tumor and normal tissues) were collected; the total RNA was extracted by TRIzol, and qPCR was used to detect mRNA levels of the m6A methylation complex, including WTAP, METTL3, METTL14, FTO, ALKBH, YTHDF1, YTHDF2 and YTHDF3. This evidence concerns the gene YTHDF3 and hepatocellular carcinoma.