Numerous studies expound that N6-methyladenosine (m6A) modification-related genes, including METTL3, METTL14, YTHDC1, YTHDC2, YTHDF1, YTHDF2, WTAP, ALKBH5, FTO, etc., play vital role in the development and radio resistance of many cancers 33, 34. The gene discussed is METTL3; the disease is cancer.