All results showed that WTAP (p=0.0011), METLL14 (p=0.0044) and YTHDF3 (p=0.0472) were decreased in tumor tissues compared to normal tissue, meanwhile, there are no significant difference among the two groups in METTL3 (p=0.6485), FTO (p=0.1158), ALKBH (p=0.6148), YTHDF1 (p=0.3171), and YTHDF2 (p=0.1116) (Figure 1). The gene discussed is METTL3; the disease is neoplasm.