GAS2 and leukemia: 49. Furthermore, our research has demonstrated that HNRPDL plays a role in malignant transformation within hematopoietic cells, promoting the growth of CML cells and influencing their response to drugs, partially through its regulation of PBX1 50. In addition, GAS2 exhibits abnormal expression in other types of leukemia, including acute lymphoblastic leukemia (T-ALL), where it regulates T-ALL through pathways involving CXCR4 and c-MYC 14, 38.