CD274 and neoplasm: A study utlizing xenograft assays and manipulating AIM2 expression in tumor cells in vitro demonstrated that AIM2 facilitates immune evasion in LUAD by inducing M2 macrophage polarization and PD-L1 expression via the JAK/STAT3 pathway, while also inhibiting CD8+ T cell infiltration through the PD-1/PD-L1 axis57.