Studies of a DFNB12 mouse model (erl mouse) in which deafness is caused by a Cdh23 point mutation revealed that expression of BiP and CHOP in outer hair cells (OHCs), SGNs, and stria vascularis increased significantly, and confirmed that apoptosis was inhibited significantly after CHOP knockout (Hu et al., 2016). The gene discussed is CDH23; the disease is deafness.