Utilizing the cytoHubba plugin, we identified several DEGs in central positions, including SERPINE1, PRKG2, AGTR1, IL-6, CCL2, and ACTB in the SSc dataset, and PROM1, FGF2, VEGFA, SPP1, PRKG2, and BDNF in the LUAD dataset (Figures 2B,D). Here, SPP1 is linked to systemic sclerosis.