Although the PRKG2 expression levels in pulmonary fibroblasts from SSc-ILD patients compared to those from the normal population in the GSE40839 dataset showed no statistically significant difference, PRKG2 expression levels in pulmonary fibroblasts from SSc-ILD lungs were lower than those in normal lung tissues in both datasets (GSE231693 and GSE40839), with this difference being statistically significant in the GSE231693 dataset. This evidence concerns the gene PRKG2 and systemic sclerosis.