Contrarily, TMPRSS2 rs2070788 A and rs4818239 C alleles were significantly associated with a two- to three-fold decrease in the likelihood of developing severe COVID-19 in both females and males (Table 2), while the odds for in-hospital death decreased in the presence of rs2070788 A and rs4818239 C in females and males, respectively (Table 4). The gene discussed is TMPRSS2; the disease is COVID-19.