MAPT and Alzheimer disease: We also found a significant main effect of genotype for insoluble pathological tau (Figure 9E), with 3xTg-AD showing higher levels of T181 (t(10) = 8.857, p < 0.0001) and S396 (t(10) = 34.97, p < 0.0001) than NonTg counterpart, collectivity validating the presence of humanized Aβ and tau pathogenesis in 3xTg-AD mice.