miR-342-3p, which shares conserved seed regions with SORL1 and CACNA1C, has shown consistent upregulation in APP-PS1 mouse brain tissue over time (Wang et al., 2017) as well as in hippocampal samples from human AD patients and 3xTg AD mice (Fu et al., 2019). The gene discussed is PSEN1; the disease is Alzheimer disease.