miR-140-3p, which is abundant in the brain (Shao et al., 2010), shares conserved seed regions with BACE1, BCL2, and SIRT1. miR-374c-5p targets several AD-associated genes, including APP, BACE1, PSEN1, CACNA1C, BCL2, and ATG12. This evidence concerns the gene SIRT1 and Alzheimer disease.