APOE and Alzheimer disease: ApoE isoforms differentially influence various aspects of AD pathology, including Aβ aggregation and clearance, tau pathology, innate immune response, synaptic integrity, glucose metabolism, cerebrovascular function, and age-related cognitive decline (Kim et al., 2009; Liu et al., 2013; Safieh et al., 2019; Yamazaki et al., 2019; Raulin et al., 2022).