CHUK and neoplasm: Next, we searched for 20 genes associated with TNF (Fig. S5B), the five signaling pathways associated with tumors were enriched by GO functional analysis and included positive regulation of cytokine production, I-kappa B kinase/NF-kappa B signaling, regulation of T cell activation, regulation of the T cell-mediated immune response to tumor cells, and cell response to tumor necrosis factor (Fig. S5C).