CCDC8 and urinary bladder carcinoma: This is consistent with the literature indicating that metabolic reprogramming is essential for bladder cancer development and progression22-24.Metabolic reprogramming is a hallmark of cancer, allowing tumor cells to sustain rapid proliferation and survive under adverse conditions25.This metabolic shift supports the biosynthetic needs of rapidly dividing cells and contributes to an acidic tumor microenvironment, which can promote invasion and metastasis26, 27.The involvement of CCDC8 in metabolic reprogramming highlights its potential as a therapeutic target.