Second, SSC-A on CD14+ monocyte mediated the pathway from Sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1) to CRC with a mediation effect of 0.0155 (95% CI [-0.023, 0.054], P = 0.036), accounting for 11.72% of the total effect (Table 1, Figure 6). This evidence concerns the gene CD14 and colorectal carcinoma.