Among these, 14 immune cell traits were associated with increased risk of CRC, including HLA DR++ monocyte %leukocyte, CD127 on T cell, CD3 on CD28- CD8+ T cell, etc. with HLA DR++ monocyte %leukocyte showing the most significant effect (OR = 1.075, 95% CI [1.005, 1.150], P = 0.036). Here, CD8A is linked to colorectal carcinoma.