SSC-A on CD14+ monocyte, CD3 on CD28- CD8+ T cell mediated the effects of Sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/ 24:1), and 16a-hydroxy-DHEA-3-sulfate on CRC risk. Here, CD14 is linked to colorectal carcinoma.