We found that two plasma metabolites, Sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1) and 16a-hydroxy-DHEA-3-sulfate, influence CRC through mediation by two immune cell traits, SSC-A on CD14+ monocyte and CD3 on CD28- CD8+ T cell. The gene discussed is CD28; the disease is colorectal carcinoma.