METTL16 and cholangiocarcinoma: We analyzed the the expression of METTL16 in CC cell lines by DepMap (Figure S1A), and constructed METLL16-knockdown and METLL16-overexpressing cells in KMBC and RBE by siRNAs and METTL16 overexpression plasmid to define the functions of METTL16 in CC (Figure 2A and B).