METTL16 and cholangiocarcinoma: Furthermore, we employed liproxstatin and ferrostatin-1 to inhibit ferroptosis in KMBC and RBE cells and found that METTL16 knockdown slows cell proliferation which is rescued by liproxstatin or ferrostatin-1 (Figure 4C), suggesting that METTL16 knockdown promotes ferroptosis in CC.