The mTOR signaling pathway is well-established in cancer biology, orchestrating vital functions, including survival, apoptosis, angiogenesis, and autophagy through phosphorylation-mediated inactivation of the translational repressors, including eukaryotic initiation factor 4E (eIF4E) and 4E binding protein 1 (4EBP1). The gene discussed is EIF4E; the disease is cancer.