In these studies conducted on adults, BMI and waist circumference values of individuals with the CC genotype of the CLOCK rs3749474 gene were found to be lower than those with the TT genotype (29), and minor allele carriers at least one copy of the T allele at the CLOCK rs3749474 displayed a significantly higher degree of obesity (weight and BMI) and abdominal obesity (waist circumference) than major allele carriers (62). This evidence concerns the gene CLOCK and obesity due to melanocortin 4 receptor deficiency.