On the other hand, the logistic regression analysis revealed that low energy intake (%) at breakfast increased the risk of overweight/obesity in common homozygous genotypes for the CLOCK rs3749474 and rs1801260 (OR: 3.171; OR: 2.467, respectively), as well as minor G allele carriers for the CLOCK rs4580704 (OR: 2.148). Here, CLOCK is linked to obesity due to melanocortin 4 receptor deficiency.