The canonical pathway analysis shows inhibition of signaling of PTEN-phosphatase and tensin homolog, RHOGDI-Rho guanine nucleotide dissociation inhibitors and type I diabetes mellitus in ECs, with activation of signaling of RHO GTPase cycle, FAK and pathogen induced cytokine storm pathway (Figure 3D). The gene discussed is RHO; the disease is type 1 diabetes mellitus.