Figures 6A-6B are 160790-cross analyses for aortic aneurysm, showing for activated signaling (e.g., ANGPT2- Angiopoietin 2, F2R-coagulation factor II thrombin receptor, AGT- angiotensinogen, TGFβ1, IL1B and CCR2- C-C motif chemokine receptor 2) and inhibited signaling (e.g., APOE-apolipoprotein E, FBN1-fibrillin 1, NOS3-nitric oxide synthase 3, and SNX1-sorting nexin 1). The gene discussed is FBN1; the disease is aortic aneurysm.