Notably, CRT-NP treatment enhanced CD4+ T helper cell populations (3.5-4 folds) in both genders and promoted the infiltration of total macrophages (3.5 folds in female & 2 folds in male) and M1 macrophages (~3.5 folds in female & 2.5 folds in male) with decline (~2 folds in female) in M-MDSC infiltration within the tumor microenvironment (TME; Figure 4B-C). The gene discussed is CD4; the disease is neoplasm.