To investigate the role of blocking endothelial autophagy in tumor vasculature and immune microenvironment optimization, we utilized endothelial cell-specific Atg7 conditional knockout (Atg7iECKO) mice generated by crossing VE-Cadherin-Cre-ERT2 transgenic mice with Atg7-floxed mice. The gene discussed is CDH5; the disease is neoplasm.