SCAP and viral infectious disease: Conversely, endoplasmic reticular (ER) stress, DNA damage, WNT/Beta-catenin, and sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP)/SREBP were significantly enriched signaling-related pathways in the MARV-infected R. aegyptiacus-derived RoNi/7.1 immortalized kidney cell line, whereas pathways related to viral infection response, IFN-alpha/beta signaling, and oxidative stress response were notably upregulated in the MARV-infected H. sapiens primary proximal tubular cell line (Figure 5B).