GSK3B and colorectal carcinoma: In this study, in vitro and in vivo experimental data showed that PCCA upregulation promotes the progression and metastasis of CRC, which is associated with epithelial-mesenchymal transition (EMT), the activation of the extracellular signal-regulated kinase (ERK)/glycogen synthase kinase 3 beta (GSK3β) signaling pathway, and the suppression of M1-macrophage polarization.