Subsequently, we identified four co-diagnostic genes (PMP22, QSOX1, REV3L, SP110) for endometriosis and SLE, and comprehensively analyzed their biological characteristics, including protein interactions, functional annotations, multifactorial regulatory network, immune infiltration, potential target drugs prediction, and expression validation, to deeply explore the potential common pathogenic mechanisms between the two diseases. This evidence concerns the gene REV3L and endometriosis.