ACHE and neurodegenerative disease: These composition ameliorated the learning and memory impairment induced by Aβ1-40 through increasing choline acetyltransferase (CHAT) activity and decreased acetylcholinesterase (AChE) activity in the cortical and hippocampal tissue, implying that porphyrin might be the potential agents to target aging-related neurodegenerative disease (Zhang Z. et al., 2020).