Among these isoforms, HKII has garnered significant attention due to its abnormally elevated expression levels in a variety of cancers, which is closely associated with the metabolic reprogramming and progression of tumors (Roberts and Miyamoto, 2015; Li R. et al., 2022; DeWaal et al., 2018; Ciscato et al., 2021; Lee et al., 2019). Here, HK2 is linked to cancer.