Key enzymes in fatty acid synthesis, such as Fatty Acid Synthase (FASN), Acetyl-CoA Carboxylase (ACC), and ATP Citrate Lyase (ACLY), are upregulated in various cancers and are closely associated with tumor progression (Paul et al., 2022; Menendez and Lupu, 2017; Menendez and Lupu, 2007; Wang Y. et al., 2022; Yu et al., 2023; Wang et al., 2015; Khwairakpam et al., 2015; Merino et al., 2017). The gene discussed is ACLY; the disease is neoplasm.