Amino acids not only provide energy and biosynthetic precursors for the rapid growth of tumor cells (Vettore et al., 2020; Qiu et al., 2023), but also the high expression of certain amino acid metabolic enzymes, such as asparaginase, which plays a role in the treatment of leukemia, and the enhancement of branched-chain amino acid (BCAA) metabolism, may promote the migration and invasion of tumor cells (Qian et al., 2023). This evidence concerns the gene ASPG and neoplasm.