ROC curve successfully marked cutoff point ≥42.35 for total lesion glycolysis (TLG) and  12.75 for metabolic tumor value (MTV) that are capable to discriminate positive versus negative HER2 expression in breast cancer patients with area under curve (AUC) 0.728 and 0.723 and P-values 0.002 and 0.004 respectively. Here, ERBB2 is linked to breast carcinoma.