Genetic factors related to ER stress, such as orosomucoid-like 3 (ORMDL3), contribute to asthma development by influencing calcium homeostasis, ER stress response, and inflammatory processes (Schmiedel et al., 2016; Breslow et al., 2010; Luthers et al., 2020). The gene discussed is ORMDL3; the disease is asthma.