In vitro experiments have demonstrated that knockdown of PCAT19 or overexpression of miR-142-5p decreases glioma cell proliferation, colony formation, and invasion, while promoting apoptosis by modulating the expression of Cyclin B1, CDK2, N-cadherin, Bcl-2, Bax, and E-cadherin. The gene discussed is PCAT19; the disease is central nervous system cancer.