The loss of E-cadherin functionality by ZEB1 (transcription factor controlling the differentiation of cancer cells, and metastasis) (217) and ZEB2 (a role in epithelial-mesenchymal transition–dependent tumor metastasis) (218) during epithelial-to-mesenchymal transition (EMT), leads to enhanced migration and invasion, influencing cancer prognosis. Here, ZEB1 is linked to cancer.