LGALS3 and neoplasm: In addition to MHC-II, LAG-3 also binds to other ligands, such as liver sinusoidal endothelial cell lectin (LSECtin), Galectin-3 (Gal-3), and fibrinogen-like protein 1 (FGL1), which further inhibit T cell function and promote tumor immune evasion (24, 25).