further elucidated the functional and mechanistic roles of LAG-3, demonstrating that both LAG-3 and sLAG-3 transfected cells protect MHC-II-positive melanoma cells from FAS-induced and drug-induced apoptosis, primarily through activation of the MAPK/ERK and PI3K/AKT signaling pathways (37). The gene discussed is LAG3; the disease is melanoma.